They want content that will draw an audience live but is of no interest to people after-the-fact (No more show recording or archiving.)
They want people who expect to engage their friends and acquaintances over several platforms, OR who don't engage with each other at all outside of the cast. (Elimination of messaging. Disinterest in replacing the PM function and the /invite command. Disinterest in fixing the Followers pages, and then elimination thereof.)
They want content that can be pre-empted randomly by ads without losing its appeal. OR they want people who will commit to a Pro account. (Insertion of mid-roll ads.)
They don't want porn but they are OK with crude, offensive, or threatening behavior. (Relaxation of the TOS. Reduction in Admin tools.)
They accept viewers and casters as young as 13, based on the user's self-reported age. Identity authentication is minimal. Anonymity is fine.
Put that all together and what do you get? Heck if I know! Actually, I think their relatively new Creativity section might fit right in. Creativity often shows people doing a process that takes a long time to complete. Like sculpting. I doubt Creativity will have the legs that gaming does at Twitch, but you never know. That might be an exploitable niche.